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Warframe: Best Pox Builds

Patricia Arquette
Release: 2025-03-23 00:40:09
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The Pox is one of Warframe's stranger weapons. These Infested pus sacks act as toxic grenades that debuff targets on impact, covering a wide area in noxious gas. You can make this weapon a powerful status primer with the right build and loadout synergies.

Warframe: Best Pox Builds

If you're looking for a decent utility weapon or love status procs, then the Pox and its Coda variant are likely up your alley. Today, we'll be looking at how to craft the Pox, showcase some of its quirks, and give you a solid status primer build to make the Pox a standout option in high-end Star Chart content and early Steel Path missions.

How To Obtain The Pox

Warframe: Best Pox Builds

The base version of the Pox can be obtained from the Bio Lab in your clan's dojo. You'll need to be part of a clan to gain entry to a clan dojo, which means clan membership is a requirement for obtaining the base Pox without spending Platinum.

Later in your journey, you'll be able to get your hands on the Coda Pox through Eleanor's Coda shop in Hollvania. Complete " The Hex " quest to access all Warframe 1999 content, defeat a Technocyte Coda , then speak with Eleanor to grab a Coda Pox.

Pox Crafting Requirements

4 Mutagen Mass

6,500 Nano Spores

1,200 Rubedo

2 Nitain Extract

Credit Cost: 30,000

Build Time: 24 Hours

Warframe: Best Pox Builds

Pox Stats And Features

Warframe: Best Pox Builds

Base Damage

Pox

Coda Pox

Toxin

20 (x4)

35 (x4)

Total

80

140

Other Damage Stats

Multishot

1

1

Fire Rate

2.08

2.08

Critical Chance

1%

10%

Critical Multiplier

2x

2.2x

Status / Projectile

35%

45%

Misc.

Weapon Type

Pistol

Trigger Type

Auto

Accuracy

Very High

Magazine

4

8

Reload Speed

1s

1s

MR Requirement

MR 9

MR 17

The Pox is a pair of Infested projectiles that are thrown from your hands, detonating on impact. Each projectile creates a lingering Toxin cloud on impact, dealing Toxin damage every second for the next four seconds. Damage ticks aren't potent in terms of damage, but they have fairly high base status chance.

You're best off using the Pox as a status primer, using the toxic clouds as a form of area denial for weaker targets and a general debuff tool for tougher units. The intrinsic Toxin damage makes this weapon a good candidate for Corrosive or Viral status.

Pox Builds

Warframe: Best Pox Builds

We'll be focusing on one build for the Pox today, focusing on the weapon's high status chance to create a powerful status primer. If you want to make this weapon a solid DPS option in Steel Path, we suggest using the Coda variant and focusing on external critical sources like Arcane Avenger. For our purposes, priming targets with status debuffs should be more than enough.

Status Primer

Warframe: Best Pox Builds

Forma

2 (V, –)

Variant

Coda Pox

The main goal with this build is to get your status chance to roughly 100 percent while scaling the weapon's status damage. We can accomplish the former with 60/60 elemental mods—Pistol Pestilence, Frostbite, and Scorch. Since we inflict quite a few status effects, we can use Primed Heated Charge to drastically increase our Heat proc chance and the Pox's overall damage.

Use Viral + Heat to maximize your damage against most factions.

Base damage is up next. Hornet Strike is your only option since Galvanized Aptitude doesn't work for AoE damage. You can also run Cascadia Flare as your Arcane for an extra 480 percent base damage; it is always active since we constantly proc Heat status. Galvanized Diffusion and Lethal Torrent then scale our multishot. Finish the build with Pistol Elementalist to scale your elemental DoT effects.

Warframe: Best Pox Builds

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