Antidote Charm Guide for Path of Exile 2

The Antidote Charm is a useful item in Path of Exile 2 (PoE 2) that protects you from poison. This guide will explain what it does, when to use it, and how to find it.

Note: You can find all Charm guides here.

What Does the Antidote Charm Do?

• Grants Immunity to Poison: When you get poisoned, this charm activates and makes you immune to poison for 3 seconds.

• Automatic Activation: It works on its own when you get poisoned. No need to press anything.

• Uses Charges:

  • The charm has 80 charges in total.

  • Each use consumes 40 charges.

  • You refill charges by killing monsters or using Wells.

• Level Requirement: You need to be Level 24 to use it.

When Should You Use It?

The Antidote Charm is great for areas or fights where enemies or traps frequently apply poison. Poison can deal a lot of damage over time, so immunity can save your life.

Best Times to Use It:

• In Poison-heavy Areas: Some maps or regions are full of poison traps or enemies that inflict poison.

• Against Poison-focused Bosses: Certain bosses rely heavily on poison to deal damage.

• If You Lack Poison Resistance: If your gear doesn’t provide enough poison resistance, this charm can keep you safe.

How Do You Get the Antidote Charm?

• Dropped by Enemies: The charm can drop randomly from monsters or chests throughout the game.

• Early to Mid-Game Zones: Since it requires Level 24, you may be more likely to find it in earlier game areas compared to higher-level charms.

Tips for Using the Antidote Charm

1. Equip It in Your Belt:

   • The charm only works when it’s placed in a belt slot.

2. Refill Its Charges:

   • Charges are restored as you kill monsters or use Wells. Check your charges before entering poison-heavy areas.

3. Combine It with Other Defenses:

   • Pair it with flasks or gear that reduce poison duration or increase chaos resistance to further protect yourself.

4. Plan for Poison Encounters:

   • Use this charm when exploring maps or areas with known poison effects.

The Antidote Charm is a simple yet powerful tool to handle poison threats in Path of Exile 2. Keep it equipped, watch your charges, and stay prepared for any poisonous enemies or traps you face. Good luck and stay safe!

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