Use an editor first, such as Notepad++. If it doesn't work, copy a copy to the desktop, then modify the desktop copy, and then replace the original one with the desktop copy!
It may be a problem with the system's C drive permissions. After modification, you can save it to the desktop first, and then replace the files in C:\Windows\System32\drivers\etc
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The file is set to read-only, C:\Windows\System32\drivers\etc, cancel the read-only attribute
Use an editor first, such as Notepad++. If it doesn't work, copy a copy to the desktop, then modify the desktop copy, and then replace the original one with the desktop copy!
It may be a problem with the system's C drive permissions. After modification, you can save it to the desktop first, and then replace the files in C:\Windows\System32\drivers\etc
Open with an editor, not Notepad