python 一次性替换多个字符

Question

a = 'New York,NY2016'
如何一次性把空格替换成+号，然后逗号替换成%
用replace貌似只能替换一个，能多个吗？
谢谢

Answer 1

a.replace(' ','+').replace(',','%')

Answer 2

Can write a regular expression

Answer 3

Try using translation